Few days ago a client requested the configuration of MSDTC (Microsoft Distributed Transaction Coordinator).
NOTE: If you want to know more about it here is a nice FAQ from Microsoft blogs - MSDTC Recommendations on SQL Failover Cluster ?
The client has 2 machines: one an application server and one a database server.
Both run on Windows Server 2016 OS and, the database server runs SQL Server 2016 using Availability Groups feature (where their databases resides).